Author: Xavier Hernandez-Alias; Martin Schaefer; Luis Serrano
Title: Translational adaptation of human viruses to the tissues they infect Document date: 2020_4_7
ID: 0rk2dw4e_3
Snippet: Here, we systematically analyze the relative codon usage landscape of over 500 humaninfecting viruses together with the recently published tRNA expression profiles of human tissues 2 . Among other viral annotated features, including phylogeny and Baltimore classification, their tissue tropism explains more variance in codon usage than the other tested features. In consequence, tropism corresponds with codon optimization patterns that can be assoc.....
Document: Here, we systematically analyze the relative codon usage landscape of over 500 humaninfecting viruses together with the recently published tRNA expression profiles of human tissues 2 . Among other viral annotated features, including phylogeny and Baltimore classification, their tissue tropism explains more variance in codon usage than the other tested features. In consequence, tropism corresponds with codon optimization patterns that can be associated with tissue-specific profiles of tRNA-based translation efficiencies.
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