Author: Joseph C. Ward; Lidia Lasecka-Dykes; Chris Neil; Oluwapelumi Adeyemi; Sarah Gold; Niall McLean; Caroline Wright; Morgan R. Herod; David Kealy; Emma Warner; Donald P. King; Tobias J. Tuthill; David J. Rowlands; Nicola J. Stonehouse
Title: The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication but essential for the production of infectious virus Document date: 2020_1_11
ID: ahrrphm8_25
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01.10.901801 doi: bioRxiv preprint 21 copy of PK1 or PK4. This observation is consistent with a previous report of deletion of PK1, 473 along with the Poly-C-tract, with no adverse effect in viral replication (37). This also supports 474 our findings that the truncation of the Poly-C-tract to create the C11 construct had no effect on 475 rep.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01.10.901801 doi: bioRxiv preprint 21 copy of PK1 or PK4. This observation is consistent with a previous report of deletion of PK1, 473 along with the Poly-C-tract, with no adverse effect in viral replication (37). This also supports 474 our findings that the truncation of the Poly-C-tract to create the C11 construct had no effect on 475 replicon replication in the cell lines tested. As has been described with Mengo virus, it is 476 possible that the role of the poly-C-tract is essential in other aspects of the viral lifecycle which 477 cannot be recapitulated in a standard tissue culture system (39).
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