Author: Xavier Hernandez-Alias; Martin Schaefer; Luis Serrano
Title: Translational adaptation of human viruses to the tissues they infect Document date: 2020_4_7
ID: 0rk2dw4e_21
Snippet: In an attempt to elucidate the translational selection that could have benefitted the evolution of the new coronavirus, we also compared the SDA adaptation of SARS-CoV-2 to those of close phylogenetic strains: the human-infecting SARS-CoV and the bat coronavirus RatG13, with 79.6% and 96.2% of sequence identity, respectively 33 . We observe that all four main proteins of the new strain have optimized their codon usage with regard to the previous .....
Document: In an attempt to elucidate the translational selection that could have benefitted the evolution of the new coronavirus, we also compared the SDA adaptation of SARS-CoV-2 to those of close phylogenetic strains: the human-infecting SARS-CoV and the bat coronavirus RatG13, with 79.6% and 96.2% of sequence identity, respectively 33 . We observe that all four main proteins of the new strain have optimized their codon usage with regard to the previous 2003pandemic SARS-CoV (Extended Data Fig. 2B ). On the other hand, even though the ratio of synonymous versus nonsynonymous mutation rate of the bat coronavirus compared to SARS-CoV-2 is exceptionally high 38 , their proteins are very similarly adapted to most human tissues.
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