Author: Xavier Hernandez-Alias; Martin Schaefer; Luis Serrano
Title: Translational adaptation of human viruses to the tissues they infect Document date: 2020_4_7
ID: 0rk2dw4e_26
Snippet: Previous studies on the translational adaptation of the human immunodeficiency virus 1 suggested that the host tRNA pool is reprogramed upon viral infection in order to favor the expression of late genes 17 . In this direction, we wanted to test whether this tRNA reprogramming is a general adaptive mechanism among viral species. Using three previously published small RNA-sequencing datasets of human cell lines upon viral infection [40] [41] [42] .....
Document: Previous studies on the translational adaptation of the human immunodeficiency virus 1 suggested that the host tRNA pool is reprogramed upon viral infection in order to favor the expression of late genes 17 . In this direction, we wanted to test whether this tRNA reprogramming is a general adaptive mechanism among viral species. Using three previously published small RNA-sequencing datasets of human cell lines upon viral infection [40] [41] [42] , we quantified the tRNA of mock and productive infections at different time points (Sup. Table 6 ). Therefore, for all datasets, we detected a general decrease in translational efficiency upon . CC-BY 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.06.027557 doi: bioRxiv preprint viral infection, with late viral proteins being more favored than early ones specifically at longer infection times (Fig. 4C) .
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