Author: Junan Zhu; Kristina Rivera; Dror Baron
Title: Noisy Pooled PCR for Virus Testing Document date: 2020_4_11
ID: f07zk05y_54
Snippet: Another question is whether the false positive probability, p 2 , is identical for all measurements. Alternately, p 2 may depend on the measurement system, for example the number of samples pooled together, or the number of RT-PCR iterations. If individual RT-PCR iterations are costly, then the number of iterations can be reduced, resulting in larger p 2 . Our experience with AMP-based algorithms suggests that a modest increase in R = M/N will co.....
Document: Another question is whether the false positive probability, p 2 , is identical for all measurements. Alternately, p 2 may depend on the measurement system, for example the number of samples pooled together, or the number of RT-PCR iterations. If individual RT-PCR iterations are costly, then the number of iterations can be reduced, resulting in larger p 2 . Our experience with AMP-based algorithms suggests that a modest increase in R = M/N will compensate for the degraded individual measurements. Cost effectiveness of each iteration will determine the number of times each sample can be run. This value should be weighed against the number of times individual samples are pooled, allowing to optimize the number of samples pooled per measurementà la [3] .
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