Selected article for: "disease pathogenesis and early occur"
Author: Tian, Wenmin; Zhang, Nan; Jin, Ronghua; Feng, Yingmei; Wang, Siyuan; Gao, Shuaixin; Gao, Ruqin; Wu, Guizhen; Tian, Di; Tan, Wenjie; Chen, Yang; Gao, George Fu; Wong, Catherine C. L.
Title: Immune suppression in the early stage of COVID-19 disease
  • Cord-id: 4dkvs78f
  • Document date: 2020_11_17
    • ID: 4dkvs78f
    Snippet: The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and sever
    Document: The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies.

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