Author: David Brann; Tatsuya Tsukahara; Caleb Weinreb; Darren W. Logan; Sandeep Robert Datta
Title: Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients Document date: 2020_3_27
ID: bb4h255w_89
Snippet: author/funder. All rights reserved. No reuse allowed without permission. Fig. 2A for three bulk RNA-sequencing datasets. MHV, mouse hepatitis virus. Left plot is same as Fig. 2A except for the addition of Ceacam1. (B) CoV-2 related genes Ace2 and Tmprss2, as well as marker genes for cell types in Fig. 2C ., in UMAP representation of WOM dataset with normalized expression. Gfap-positive OECs (olfactory ensheathing cells) and Muc5b-positive secreto.....
Document: author/funder. All rights reserved. No reuse allowed without permission. Fig. 2A for three bulk RNA-sequencing datasets. MHV, mouse hepatitis virus. Left plot is same as Fig. 2A except for the addition of Ceacam1. (B) CoV-2 related genes Ace2 and Tmprss2, as well as marker genes for cell types in Fig. 2C ., in UMAP representation of WOM dataset with normalized expression. Gfap-positive OECs (olfactory ensheathing cells) and Muc5b-positive secretory cells are indicated by asterisks. (C) Gene expression for CoV-related genes including Ace2 and Tmprss2 as well as marker genes for olfactory and RE subtypes are shown normalized by their maximum expression across cell types. Ace2 and Tmprss2 are expressed in WOM respiratory and olfactory cell types, but not in OSNs. author/funder. All rights reserved. No reuse allowed without permission.
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