Risk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil

da Silva, Patricia Vieira; de Oliveira, Silvano Barbosa; Escalante, Juan José Cortez; Almiron, Maria; Tsuha, Daniel Henrique; Sato, Helena Keico; Menezes, Paulo Rossi; de Paula, Regiane Cardoso; D’Agostini, Tatiana Lang; Croda, Julio

São Paulo is a state in Brazil with one of the highest numbers of confirmed and severe cases of coronavirus disease (COVID-19), with an incidence of 294 hospitalizations per 100,000 inhabitants. We report the clinical characteristics and outcomes of 120,804 hospitalized patients with confirmed COVID-19 from February 26 to October 10, 2020, in São Paulo. Characteristics of patients who died and survived were compared using a survival analysis. The median age was 60 years (interquartile range [IQR], 47–72), 67,821 (56.1%) were men, and 61,659 (51.0%) were white. Most hospitalized patients (79,812; 66.1%) reported one or more comorbidities, 41,708 (34.5%) hospitalized patients were admitted to intensive care units, and 33,079 (27.4%) died. Men (hazard ratio [HR], 1.22; 95% confidence interval [CI], 1.18–1.25), elderly individuals (HR, 3.85; 95% CI, 3.68–4.02), and patients with chronic cardiovascular disease including hypertension (HR, 1.05; 95% CI, 1.02–1.08), chronic lung disease (HR, 1.38; 95% CI, 1.31–1.45), diabetes mellitus (HR, 1.14; 95% CI, 1.11–1.18), and chronic neurological disease (HR, 1.48; 95% CI, 1.41–1.55) were at higher risk for death from COVID-19.