Author: Jing Qi; Yang Zhou; Jiao Hua; Liying Zhang; Jialin Bian; Beibei Liu; Zicen Zhao; Shuilin Jin
Title: The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection Document date: 2020_4_18
ID: grvc7pnt_21
Snippet: The scRNA-seq data of jejunum, ileum, duodenum, rectum, colon, esophagus, gall bladder, pancreatic islets, liver, and stomach from the digestive system were collected for the analysis. The primordium cells from the gall bladder contain 2· 6% TMPRSS2-expressed cells and 2· 2% ACE2-expressed cells (Fig. 2, Table 3 ), which means the gall bladder is vulnerable to the COVID-19 infection. Moreover, small intestine (jejunum, ileum, and duodenum), lar.....
Document: The scRNA-seq data of jejunum, ileum, duodenum, rectum, colon, esophagus, gall bladder, pancreatic islets, liver, and stomach from the digestive system were collected for the analysis. The primordium cells from the gall bladder contain 2· 6% TMPRSS2-expressed cells and 2· 2% ACE2-expressed cells (Fig. 2, Table 3 ), which means the gall bladder is vulnerable to the COVID-19 infection. Moreover, small intestine (jejunum, ileum, and duodenum), large intestine (rectum and colon), and esophagus are identified as high-risk organs (Supplementary File: Figures S14-S19, Table 3 ). However, no cell clusters from the liver, stomach, and pancreatic islets data show high ACE2 and TMPRSS2 expression level (Supplementary File: Figures S20-S22) , which demonstrates a low infection risk.
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