Author: Chen, Yanqiong; Tao, Huan; Shen, Silan; Miao, Zhiyong; Li, Lili; Jia, Yongqian; Zhang, Hu; Bai, Xiufeng; Fu, Xinyuan
Title: A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2 Cord-id: 8a9ey8lu Document date: 2020_8_26
ID: 8a9ey8lu
Snippet: The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus. This study aimed to successfully develop a toolkit for screening antiviral drugs. Finally, the FDA-approved drug library was screened, revealing that ivacaftor and (–)-Huperzine A worked well in changing the –1 ribosomal frameshifting of SARS-CoV-2
Document: The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus. This study aimed to successfully develop a toolkit for screening antiviral drugs. Finally, the FDA-approved drug library was screened, revealing that ivacaftor and (–)-Huperzine A worked well in changing the –1 ribosomal frameshifting of SARS-CoV-2 in vitro.
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