Author: Mark Hernandez; Lauren E Milechin; Shakti K Davis; Rich DeLaura; Kajal T Claypool; Albert Swiston
Title: The Impact of Host-Based Early Warning on Disease Outbreaks Document date: 2020_3_8
ID: 8874c8jp_45
Snippet: • Disease characteristics: prevalence, transmissibility, incubation period, and severity An element that we do not include in our model is patient care measures, which are nearly always more effective when deployed earlier than overt indications of infection (e.g., fever). For instance, antiviral drugs (such as zanamivir and oseltamivir/Tamiflu) are most effective in the first ~48 hours of symptoms [8, 17, 18] ; PRESAGED-enabled early warning w.....
Document: • Disease characteristics: prevalence, transmissibility, incubation period, and severity An element that we do not include in our model is patient care measures, which are nearly always more effective when deployed earlier than overt indications of infection (e.g., fever). For instance, antiviral drugs (such as zanamivir and oseltamivir/Tamiflu) are most effective in the first ~48 hours of symptoms [8, 17, 18] ; PRESAGED-enabled early warning would allow much faster prescription, use, and potentially more profound therapeutic impact for current dosage recommendations. Triggering the use of diagnostics early would allow clinicians to target drugbased interventions, such as using the precise antibiotic for bacterial infections rather than relying on broad-spectrum versions that contribute to the evolution of drug-resistant bacteria ("superbugs"). Finally, simple supportive care for mild infections, e.g., having rehydrating solutions or over-the-counter symptom-relieving medications available, could ease the burden on health care workers in hospitals, nursing homes, or college campuses. All of these exciting possibilities could be enabled or improved with earlier detection. All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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