Author: Steffen Jockusch; Chuanjuan Tao; Xiaoxu Li; Thomas K. Anderson; Minchen Chien; Shiv Kumar; James J. Russo; Robert Kirchdoerfer; Jingyue Ju
Title: Triphosphates of the Two Components in DESCOVY and TRUVADA are Inhibitors of the SARS-CoV-2 Polymerase Document date: 2020_4_5
ID: awbcw3gq_1
Snippet: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has now reached critical levels worldwide and is still spreading. SARS-CoV-2 is a member of the subgenus Sarbecovirus in the Orthocoronavirinae subfamily. 1 Coronaviruses are single-strand RNA viruses that share properties with other RNA viruses such as the hepatitis C virus (HCV), West Nile virus, Marburg virus, HIV, Ebola virus, dengue virus, and rhinoviruses. Coronaviruses, HCV.....
Document: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has now reached critical levels worldwide and is still spreading. SARS-CoV-2 is a member of the subgenus Sarbecovirus in the Orthocoronavirinae subfamily. 1 Coronaviruses are single-strand RNA viruses that share properties with other RNA viruses such as the hepatitis C virus (HCV), West Nile virus, Marburg virus, HIV, Ebola virus, dengue virus, and rhinoviruses. Coronaviruses, HCV and the flaviviruses are positive-sense single-strand RNA viruses 2,3 that share a similar replication mechanism requiring an RNA-dependent RNA polymerase (RdRp) catalyzed reaction.
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