Author: Skelly, Donal T.; Harding, Adam C.; Gilbert-Jaramillo, Javier; Knight, Michael L.; Longet, Stephanie; Brown, Anthony; Adele, Sandra; Adland, Emily; Brown, Helen; Tipton, Tom; Stafford, Lizzie; Mentzer, Alexander J.; Johnson, SÃle A.; Amini, Ali; Tan, Tiong Kit; Schimanski, Lisa; Huang, Kuan-Ying A.; Rijal, Pramila; Frater, John; Goulder, Philip; Conlon, Christopher P.; Jeffery, Katie; Dold, Christina; Pollard, Andrew J.; Sigal, Alex; de Oliveira, Tulio; Townsend, Alain R.; Klenerman, Paul; Dunachie, Susanna J.; Barnes, Eleanor; Carroll, Miles W.; James, William S.
Title: Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern Cord-id: 89fhyphs Document date: 2021_8_17
ID: 89fhyphs
Snippet: The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduce
Document: The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants.
Search related documents:
Co phrase search for related documents- acute sars respiratory syndrome coronavirus and logistic model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60
- acute sars respiratory syndrome coronavirus and london city: 1, 2
- logistic model and low magnitude: 1, 2
Co phrase search for related documents, hyperlinks ordered by date