Author: Gupta, Atula; Murrell, Dedee F.; Otton, James; Goldust, Mohamad
Title: COVID-19 Cord-id: 7a6yslpz Document date: 2020_7_7
ID: 7a6yslpz
Snippet: A novel SARS -CoV2 virus (COVID 19) that led to an outbreak of pneumonia in Wuhan, China is now known to involve multiple organ systems presenting with acute respiratory distress syndrome, gastrointestinal disease, cardiac disease, skin lesions, renal involvement, hepatic damage, and multi organ failure. Even though the mortality and morbidity of this disease is higher in the older age group, clusters of children having severe illness requiring critical care have also been identified. Severe dis
Document: A novel SARS -CoV2 virus (COVID 19) that led to an outbreak of pneumonia in Wuhan, China is now known to involve multiple organ systems presenting with acute respiratory distress syndrome, gastrointestinal disease, cardiac disease, skin lesions, renal involvement, hepatic damage, and multi organ failure. Even though the mortality and morbidity of this disease is higher in the older age group, clusters of children having severe illness requiring critical care have also been identified. Severe disease in children infected with COVID 19 is characterized by a multisystem inflammatory condition and a clinical presentation similar to Kawasaki disease. COVID 19 and its multi organ involvement is due to the underlying hyperinflammatory syndrome leading to a surge in cytokine levels causing injury to several cell types including cardiac myocytes and endothelial cells. The binding of SARS CoV2 to the ACE 2 receptor expressed in the endothelial cells, pneumocytes and myocardial cells is responsible for the clinical manifestations occurring in skin, heart and other organs.
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