Author: Myra Hosmillo; Jia Lu; Michael R. McAllaster; James B. Eaglesham; Xinjie Wang; Edward Emmott; Patricia Domingues; Yasmin Chaudhry; Timothy J Fitzmaurice; Matthew K.H. Tung; Marc Panas; Gerald McInerney; Nicholas Locker; Craig B. Willen; Ian Goodfellow
Title: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation Document date: 2019_3_8
ID: d0q5lhf4_47
Snippet: In conclusion, our data adds significantly to the growing body of literature on the role 493 of G3BP proteins in the life cycle of viruses and further extends the functional roles 494 of G3BP1 to include the promotion of viral translation processes. We identify G3BP1 495 as a host protein that has a critical role in the life cycle of murine and human 496 noroviruses, identifying the first cellular pro-viral protein with pan-norovirus activity. Th.....
Document: In conclusion, our data adds significantly to the growing body of literature on the role 493 of G3BP proteins in the life cycle of viruses and further extends the functional roles 494 of G3BP1 to include the promotion of viral translation processes. We identify G3BP1 495 as a host protein that has a critical role in the life cycle of murine and human 496 noroviruses, identifying the first cellular pro-viral protein with pan-norovirus activity. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/571455 doi: bioRxiv preprint Quantitative proteomics was used as described in the text to identify host factors that 554
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