Author: Lea Gaucherand; Brittany K. Porter; Summer K. Schmaling; Christopher Harley Rycroft; Yuzo Kevorkian; Craig McCormick; Denys A. Khaperskyy; Marta Maria Gaglia
Title: The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression Document date: 2018_10_14
ID: 8k7w467p_16
Snippet: A thorough understanding of the molecular mechanism of action of PA-X is required to 329 determine how it selectively degrades host RNAs and contributes to the control of the innate 330 immune response. In this study, we discovered a key aspect of the PA-X mechanism of action: 331 its selectivity for transcripts that have undergone splicing. Our transcriptomic results show that, 332 as expected, PA-X down-regulates many host RNAs, both on its own.....
Document: A thorough understanding of the molecular mechanism of action of PA-X is required to 329 determine how it selectively degrades host RNAs and contributes to the control of the innate 330 immune response. In this study, we discovered a key aspect of the PA-X mechanism of action: 331 its selectivity for transcripts that have undergone splicing. Our transcriptomic results show that, 332 as expected, PA-X down-regulates many host RNAs, both on its own and in the context of 333 infection. However, some RNAs are less susceptible or completely resistant to PA-X activity. 334
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