Author: Alexander M. Price; Katharina E. Hayer; Daniel P. Depledge; Angus C. Wilson; Matthew D. Weitzman
Title: Novel splicing and open reading frames revealed by long-read direct RNA sequencing of adenovirus transcripts Document date: 2019_12_13
ID: 2fcl6f4i_5
Snippet: Adenoviruses (AdV) are common viral pathogens across multiple species with distinct 37 tissue tropisms including gut, eye, and lung [1] . Among the human adenoviruses, serotypes 2 38 (Ad2) and 5 (Ad5) from subgroup C are the most prevalent within the population, and they cause 39 benign to severe respiratory infections [2] . These two serotypes are highly homologous, sharing 40 94.7% nucleotide identity between their genomes and 69.2-100% amino a.....
Document: Adenoviruses (AdV) are common viral pathogens across multiple species with distinct 37 tissue tropisms including gut, eye, and lung [1] . Among the human adenoviruses, serotypes 2 38 (Ad2) and 5 (Ad5) from subgroup C are the most prevalent within the population, and they cause 39 benign to severe respiratory infections [2] . These two serotypes are highly homologous, sharing 40 94.7% nucleotide identity between their genomes and 69.2-100% amino acid identity amongst 41 conserved open reading frames (ORFs) [3, 4] . AdVs readily infect most transformed human cell 42 lines and have proven a valuable tool that has led to seminal discoveries in molecular biology for 43 many decades [5] . RNA splicing was discovered by the analysis of adenovirus encoded RNAs 44
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