Author: Cheng, Yiâ€Qiang
Title: Deciphering the Biosynthetic Codes for the Potent Antiâ€SARSâ€CoV Cyclodepsipeptide Valinomycin in Streptomyces tsusimaensis ATCC 15141 Cord-id: 3ivzmiqn Document date: 2006_3_1
ID: 3ivzmiqn
Snippet: Valinomycin was recently reported to be the most potent agent against severe acute respiratoryâ€syndrome coronavirus (SARSâ€CoV) in infected Vero E6 cells. Aimed at generating analogues by metabolic engineering, the valinomycin biosynthetic gene cluster has been cloned from Streptomyces tsusimaensis ATCC 15141. Targeted disruption of a nonribosomal peptide synthetase (NRPS) gene abolishes valinomycin production, which confirms its predicted nonribosomalâ€peptide origin. Sequence analysis of t
Document: Valinomycin was recently reported to be the most potent agent against severe acute respiratoryâ€syndrome coronavirus (SARSâ€CoV) in infected Vero E6 cells. Aimed at generating analogues by metabolic engineering, the valinomycin biosynthetic gene cluster has been cloned from Streptomyces tsusimaensis ATCC 15141. Targeted disruption of a nonribosomal peptide synthetase (NRPS) gene abolishes valinomycin production, which confirms its predicted nonribosomalâ€peptide origin. Sequence analysis of the NRPS system reveals four distinctive modules, two of which contain unusual domain organizations that are presumably involved in the generation of biosynthetic precursors dâ€Î±â€hydroxyisovaleric acid and lâ€lactic acid. The respective adenylation domains in these two modules contain novel substrateâ€specificityâ€conferring codes that might specify for a class of hydroxyl acids for the biosynthesis of the depsipeptide natural products.
Search related documents:
Co phrase search for related documents- active site and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- active site and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- active site serine and acute respiratory syndrome: 1, 2, 3, 4, 5
- active site serine and acute sars cov respiratory syndrome coronavirus: 1, 2, 3
- acute respiratory syndrome and additional round: 1, 2, 3
- acute respiratory syndrome and additional sequencing: 1, 2, 3, 4
- acute respiratory syndrome and low cytotoxic: 1, 2, 3, 4, 5
- acute sars cov respiratory syndrome coronavirus and additional round: 1, 2, 3
- acute sars cov respiratory syndrome coronavirus and additional sequencing: 1
- acute sars cov respiratory syndrome coronavirus and low cytotoxic: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date