Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Document date: 2020_2_10
ID: 7n8p9okf_72
Snippet: After stirring for 30 min, the cooling bath was removed. The reaction mixture was allowed to warm up to room temperature and then poured into brine (40 mL). The organic layer was concentrated and purified by flash column chromatography (petroleum ether/ethyl acetate = 4/1) to give product 1 (4.92 g, 72%) as colorless oil. 1 H NMR (CDCl3, 400 MHz) δ 5.23 (1H, d, J = 9.0 Hz), 4.43-4.36 (1H, m), 3.77(1H, s), 3.76 (1H, s), 2.89-2.69 (3H, m), 2.20-2......
Document: After stirring for 30 min, the cooling bath was removed. The reaction mixture was allowed to warm up to room temperature and then poured into brine (40 mL). The organic layer was concentrated and purified by flash column chromatography (petroleum ether/ethyl acetate = 4/1) to give product 1 (4.92 g, 72%) as colorless oil. 1 H NMR (CDCl3, 400 MHz) δ 5.23 (1H, d, J = 9.0 Hz), 4.43-4.36 (1H, m), 3.77(1H, s), 3.76 (1H, s), 2.89-2.69 (3H, m), 2.20-2.14 (2H, m), 1.45 (9H, s). ESI-MS (m/z): 315 (M + H) + .
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