Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Document date: 2020_2_10
ID: 7n8p9okf_77
Snippet: Synthesis of methyl N-substituted amino-acid esters 4 General procedure. The methyl amino-acid ester hydrochloride (6.0 mmol) was dissolved in 20 mL CH2Cl2, and then acyl chloride (6.0 mmol), triethylamine (1.69 mL, 12.0 mmol) were added, before the reaction was stirred for 2 h at 20 o C. The reaction mixture was diluted with 20 mL CH2Cl2, washed with 50 mL of saturated brine (2 × 25 mL), and dried over Na2SO4. The solvent was evaporated and the.....
Document: Synthesis of methyl N-substituted amino-acid esters 4 General procedure. The methyl amino-acid ester hydrochloride (6.0 mmol) was dissolved in 20 mL CH2Cl2, and then acyl chloride (6.0 mmol), triethylamine (1.69 mL, 12.0 mmol) were added, before the reaction was stirred for 2 h at 20 o C. The reaction mixture was diluted with 20 mL CH2Cl2, washed with 50 mL of saturated brine (2 × 25 mL), and dried over Na2SO4. The solvent was evaporated and the product 4 was obtained as white solid (70-95% yield), which could be used for the next step without further purification.
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