Selected article for: "mmol ml and reaction mixture"
Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
  • Document date: 2020_2_10
    • ID: 7n8p9okf_79
    Snippet: Synthesis of N-substituted amino acids 5 (general procedure). 1 M NaOH (5 mL) was added to a solution of compound 4 (3.0 mmol) in methanol (5 mL). The reaction was stirred for 20 min at 20 o C. Then 1 M HCl was added to the reaction solution until pH = 1. Then the reaction mixture was extracted with 100 mL of CH2Cl2 (2 × 50 mL) and the organic layer was washed with 50 mL of brine and dried over Na2SO4. The solvent was evaporated and the crude ma.....
    Document: Synthesis of N-substituted amino acids 5 (general procedure). 1 M NaOH (5 mL) was added to a solution of compound 4 (3.0 mmol) in methanol (5 mL). The reaction was stirred for 20 min at 20 o C. Then 1 M HCl was added to the reaction solution until pH = 1. Then the reaction mixture was extracted with 100 mL of CH2Cl2 (2 × 50 mL) and the organic layer was washed with 50 mL of brine and dried over Na2SO4. The solvent was evaporated and the crude material purified on silica, eluted with mixtures of CH2Cl2/MeOH (20/1) to afford the product 5 (90-96% yield) as a white solid.

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