Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Document date: 2020_2_10
ID: 7n8p9okf_84
Snippet: Synthesis of α-hydroxyamides 10 (general procedure). 1 M NaOH (0.5 mL) was added to a solution of compound 9 (0.164 mmol) in methanol (5 mL). The reaction was stirred at 20 o C for 0.5 h until the consumption of compound 9 was confirmed by TLC analysis. Then, 1 M HCl was added to the reaction solution until pH = 7. Following this, the solvent was evaporated to generate the product 10 as white solid, which could be used directly in the next step......
Document: Synthesis of α-hydroxyamides 10 (general procedure). 1 M NaOH (0.5 mL) was added to a solution of compound 9 (0.164 mmol) in methanol (5 mL). The reaction was stirred at 20 o C for 0.5 h until the consumption of compound 9 was confirmed by TLC analysis. Then, 1 M HCl was added to the reaction solution until pH = 7. Following this, the solvent was evaporated to generate the product 10 as white solid, which could be used directly in the next step.
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