Author: Bandopadhyay, P.; D'Rozario, R.; Lahiri, A.; Sarif, J.; Ray, Y.; Paul, S. R.; Roy, R.; Maiti, R.; Chaudhuri, K.; Bagchi, S.; Maiti, A.; Parwez, M. M.; Sharma Sarkar, B.; Roy, D.; Chakraborty, R.; Vasudevan, J. S.; Sharma, S.; Biswas, D.; Maiti, C.; Saha, B.; Bhattacharya, P.; Pandey, R.; Chatterjee, S.; Paul, S.; Ganguly, D.
Title: Nature and dimensions of the cytokine storm and its attenuation by convalescent plasma in severe COVID-19 Cord-id: 7bagn1s7 Document date: 2020_9_23
ID: 7bagn1s7
Snippet: In a randomized control trial on convalescent plasma therapy (CPT) in severe COVID-19, we characterized the nature, in terms of abundance of forty eight cytokines, and dimensions, in terms of their interrelationships, of the hyper-immune activation-associated cytokine storm in patients suffering from acute respiratory distress syndrome. We found plasma MCP3 level to be a key correlate for mitigation of hypoxia, irrespective of therapeutic regimen. We also identified an anti-inflammatory role of
Document: In a randomized control trial on convalescent plasma therapy (CPT) in severe COVID-19, we characterized the nature, in terms of abundance of forty eight cytokines, and dimensions, in terms of their interrelationships, of the hyper-immune activation-associated cytokine storm in patients suffering from acute respiratory distress syndrome. We found plasma MCP3 level to be a key correlate for mitigation of hypoxia, irrespective of therapeutic regimen. We also identified an anti-inflammatory role of CPT independent of its neutralizing antibody content, and a linear regression analysis revealed that neutralizing antibodies as well as the anti-inflammatory effect of CPT both contribute to marked immediate reductions in hypoxia, as compared to patients on standard therapy.
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