Selected article for: "high binding affinity and viral infection"
Author: Xiaoyang Ji; Chunming Zhang; Yubo Zhai; Zhonghai Zhang; Chunli Zhang; Yiqing Xue; Guangming Tan; Gang Niu
Title: TWIRLS, an automated topic-wise inference method based on massive literature, suggests a possible mechanism via ACE2 for the pathological changes in the human host after coronavirus infection
  • Document date: 2020_3_2
    • ID: eaglecq7_2
    Snippet: Researchers have found that the new SARS-CoV-2 and SARS coronaviruses invade human cells in target tissues in a similar manner via high-affinity binding to angiotensin-converting enzyme 2 (ACE2) [1] . In recent epidemiological investigations of the spread of the SARS-CoV-2 and a preliminary study of the clinical characteristics of this disease [2] [3] [4] [5] [6] , researchers have found that patients infected with the new coronavirus have severe.....
    Document: Researchers have found that the new SARS-CoV-2 and SARS coronaviruses invade human cells in target tissues in a similar manner via high-affinity binding to angiotensin-converting enzyme 2 (ACE2) [1] . In recent epidemiological investigations of the spread of the SARS-CoV-2 and a preliminary study of the clinical characteristics of this disease [2] [3] [4] [5] [6] , researchers have found that patients infected with the new coronavirus have severe symptoms similar to those of the SARS infection. The first batch of clinical data reports of SARS-CoV-2 infection cases in China revealed "cytokine storms" in critically ill patients [7, 8] . However, the mechanism of the viral infection and pathological changes in the immune system is still lacking. The sooner this information is added to the current clinical knowledge of these viruses, the better the control and treatment of this disease.

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