Author: Ryan M. Carey; Jenna R. Freund; Benjamin M. Hariri; Nithin D. Adappa; James N. Palmer; Robert J. Lee
Title: Altered polarization of PAR-2 signaling during airway epithelial remodeling Document date: 2020_1_9
ID: 8iet67u3_10
Snippet: Controversy exists over whether certain host and pathogen proteases activate PAR-2 by cleavage at the activating site or inhibit PAR-2 by cleavage downstream, removing the tethered ligand and "disarming" it. 38 Neutrophil and Pseudomonas aeruginosa elastase have both been suggested to either activate 4, 39, 40 or disarm PAR-2. 41, 42 Differential results may be due to altered protein processing in different cell types or different assays used. We.....
Document: Controversy exists over whether certain host and pathogen proteases activate PAR-2 by cleavage at the activating site or inhibit PAR-2 by cleavage downstream, removing the tethered ligand and "disarming" it. 38 Neutrophil and Pseudomonas aeruginosa elastase have both been suggested to either activate 4, 39, 40 or disarm PAR-2. 41, 42 Differential results may be due to altered protein processing in different cell types or different assays used. We tested if several proteases implicated in allergy can activate PAR-2 expressed in airway cells, and observed activation with human lung tryptase, neutrophil elastase, and dust mite protease Der p 3 ( Supplementary Fig S2L-R) .
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