Author: Alejandro A Schäffer; Eneida Hatcher; Linda Yankie; Lara Shonkwiler; J Rodney Brister; Ilene Karsch-Mizrachi; Eric P Nawrocki
Title: VADR: validation and annotation of virus sequence submissions to GenBank Document date: 2019_11_22
ID: besvz92f_67
Snippet: Larger libraries are more likely to contain mistakes or anomalies that should not be mapped onto incoming sequences that may be automaticlly deposited in Gen-Bank. An example is the sequence FJ446720.1 from the NC dataset, which is in the VAPiD reference library but lacks annotation of the VP1 CDS. Both VADR and VIGOR failed this sequence due to a premature stop in the putative VP1 CDS, but it passed VAPiD because its reference sequence (itself) .....
Document: Larger libraries are more likely to contain mistakes or anomalies that should not be mapped onto incoming sequences that may be automaticlly deposited in Gen-Bank. An example is the sequence FJ446720.1 from the NC dataset, which is in the VAPiD reference library but lacks annotation of the VP1 CDS. Both VADR and VIGOR failed this sequence due to a premature stop in the putative VP1 CDS, but it passed VAPiD because its reference sequence (itself) lacks VP1 annotation and so the VP1 region is not examined for premature stops. This sequence may be biologically valid, but should be reviewed by GenBank indexers as opposed to being automatically deposited into Gen-Bank.
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