VADR: validation and annotation of virus sequence submissions to GenBank

Alejandro A Schäffer; Eneida Hatcher; Linda Yankie; Lara Shonkwiler; J Rodney Brister; Ilene Karsch-Mizrachi; Eric P Nawrocki

In the context of the new submissions, there is virtually no risk that a sequence of the wrong taxon would be submitted via the new GenBank submission portal interfaces for norovirus submissions and dengue virus submission. Therefore, we define that a sequences is a false positive if it passes VADR, but a GenBank indexer deems using other tools that the sequence has an error. Similarly, a sequence is a false negative if it fails VADR, but a GenBank indexer deems that the sequence should pass with no errors. Using these definitions and the counts in the previous paragraph, VADR's false positive rates are 0 for both norovirus and dengue virus. The false negative rates are 0.009 (8/906) for norovirus and 0.006 (15/2535) for dengue virus.