Author: Daniel, Y; Hunt, BJ; Retter, A; Henderson, K; Wilson, S; Sharpe, CC; Shattock, MJ
Title: Haemoglobin Oxygen Affinity in Patients with Severe COVIDâ€19 Infection Cord-id: fc86sjec Document date: 2020_5_26
ID: fc86sjec
Snippet: During critical care, at least until the late stage of the disease, severely ill COVIDâ€19 patients may have relatively well preserved lung compliance but remain severely hypoxaemic. A recent theoretical study suggested a direct interaction between COVIDâ€19 viral proteins and haemoglobin (Hb) that could lead to a loss of oxygen carrying capacity. As national guidelines strongly support a restrictive transfusion strategy in the critically ill, any rightâ€shift in the Hb O(2) affinity curve co
Document: During critical care, at least until the late stage of the disease, severely ill COVIDâ€19 patients may have relatively well preserved lung compliance but remain severely hypoxaemic. A recent theoretical study suggested a direct interaction between COVIDâ€19 viral proteins and haemoglobin (Hb) that could lead to a loss of oxygen carrying capacity. As national guidelines strongly support a restrictive transfusion strategy in the critically ill, any rightâ€shift in the Hb O(2) affinity curve could contribute to the hypoxaemia and be potentially harmful. We have measured Hb O(2) affinity curves from severely ill COVIDâ€19 patients and, in comparison to age†and sexâ€matched controls, find no evidence for a shift in O(2) affinity that would support any change in clinical management.
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