Selected article for: "measured affinity and theoretical study"

Author: Daniel, Y; Hunt, BJ; Retter, A; Henderson, K; Wilson, S; Sharpe, CC; Shattock, MJ
Title: Haemoglobin Oxygen Affinity in Patients with Severe COVID‐19 Infection
  • Cord-id: fc86sjec
  • Document date: 2020_5_26
  • ID: fc86sjec
    Snippet: During critical care, at least until the late stage of the disease, severely ill COVID‐19 patients may have relatively well preserved lung compliance but remain severely hypoxaemic. A recent theoretical study suggested a direct interaction between COVID‐19 viral proteins and haemoglobin (Hb) that could lead to a loss of oxygen carrying capacity. As national guidelines strongly support a restrictive transfusion strategy in the critically ill, any right‐shift in the Hb O(2) affinity curve co
    Document: During critical care, at least until the late stage of the disease, severely ill COVID‐19 patients may have relatively well preserved lung compliance but remain severely hypoxaemic. A recent theoretical study suggested a direct interaction between COVID‐19 viral proteins and haemoglobin (Hb) that could lead to a loss of oxygen carrying capacity. As national guidelines strongly support a restrictive transfusion strategy in the critically ill, any right‐shift in the Hb O(2) affinity curve could contribute to the hypoxaemia and be potentially harmful. We have measured Hb O(2) affinity curves from severely ill COVID‐19 patients and, in comparison to age‐ and sex‐matched controls, find no evidence for a shift in O(2) affinity that would support any change in clinical management.

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