Author: Héctor Cervera; Silvia Ambrós; Guillermo P. Bernet; Guillermo Rodrigo; Santiago F. Elena
Title: Viral fitness predicts the magnitude and direction of perturbations in the infected host transcriptome Document date: 2017_10_20
ID: 0qmsripp_12
Snippet: As before, AS13 effect on host' transcriptome is clearly different, and has negative values of pc 1 and pc 2 but positive of pc 3 . Interestingly, Fig. 3C shows that genotypes are located in this principal component space following a trajectory of increasing fitness values (indicated by the grey arrow in Fig. 3C ). Along this trajectory, pc's switch of sign but in different ways. This transition suggests that the over-or under-expression of a set.....
Document: As before, AS13 effect on host' transcriptome is clearly different, and has negative values of pc 1 and pc 2 but positive of pc 3 . Interestingly, Fig. 3C shows that genotypes are located in this principal component space following a trajectory of increasing fitness values (indicated by the grey arrow in Fig. 3C ). Along this trajectory, pc's switch of sign but in different ways. This transition suggests that the over-or under-expression of a set of genes is associated with particular levels of viral fitness: low fitness AS13 is characterized by a positive pc 3 and a negative pc 1 while high fitness viruses are characterized by the opposite sign. That is, over-or under-expressed genes are not progressively accumulated as long as viral fitness changes. These genes will be evaluated in the following sections.
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