Author: Arlin Stoltzfus; Ryan W. Norris
Title: On the causes of evolutionary transition:transversion bias Document date: 2015_9_28
ID: 4xocqn6o_53
Snippet: As noted in Materials and Methods, we restricted our attention to studies with (1) a size of at least 20 replacement mutants; (2) measures of growth (fitness) rather than simply biochemical activities; and (3) a random or arbitrary set of mutants. Most excluded studies of mutational effects have only a few mutants, or they report effects on binding or activity (but not on fitness), or they are focused on achieving particular outcomes . CC-BY 4.0 .....
Document: As noted in Materials and Methods, we restricted our attention to studies with (1) a size of at least 20 replacement mutants; (2) measures of growth (fitness) rather than simply biochemical activities; and (3) a random or arbitrary set of mutants. Most excluded studies of mutational effects have only a few mutants, or they report effects on binding or activity (but not on fitness), or they are focused on achieving particular outcomes . CC-BY 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/027722 doi: bioRxiv preprint rather than exploring a random set of variants, or they use deep sequencing to identify and quantify mutants, an approach that introduces uncontrolled nucleotide biases (Supplementary Material, section 2).
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