Multiomix: a cloud-based platform to infer cancer genomic and epigenomic events associated with gene expression modulation.

Camele, Genaro; Menazzi, Sebastian; Chanfreau, Hernán; Marraco, Agustin; Hasperué, Waldo; Butti, Matias D; Abba, Martin C

MOTIVATION Large-scale cancer genome projects have generated genomic, transcriptomic, epigenomic, and clinicopathological data from thousands of samples in almost every human tumor site. Although most omics data and their associated resources are publicly available, its full integration and interpretation to dissect the sources of gene expression modulation require specialized knowledge and software. RESULTS We present Multiomix, an interactive cloud-based platform that allows biologists to identify genetic and epigenetic events associated with the transcriptional modulation of cancer-related genes through the analysis of multi-omics data available on public functional genomic databases or user-uploaded datasets. Multiomix consists of an integrated set of functions, pipelines, and a graphical user interface that allows retrieval, aggregation, analysis and visualization of different omics data sources. After the user provides the data to be analyzed, Multiomix identifies all significant correlations between mRNAs and non-mRNA genomics features (e.g.: miRNA, DNA methylation and CNV) across the genome, the predicted sequence based interactions (e.g., miRNA-mRNA), and their associated prognostic values. AVAILABILITY Multiomix is available at https://www.multiomix.org The source code is freely available at https://github.com/omics-datascience/multiomix. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.