Author: Majnooni, Mohammad Bagher; Fakhri, Sajad; Shokoohinia, Yalda; Kiyani, Narges; Stage, Katrina; Mohammadi, Pantea; Gravandi, Mohammad Mehdi; Farzaei, Mohammad Hosein; EcheverrÃa, Javier
Title: Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury Cord-id: 9081lbte Document date: 2020_11_18
ID: 9081lbte
Snippet: Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, millions of people have been infected and died worldwide. However, no drug has been approved for the treatment of this disease and its complications, which urges the need for finding novel therapeutic agents to combat. Among the complications due to COVID-19, lung injury has attained special attention. Besides, phytochemicals have shown prominent anti-inflammatory effects and thus possess significant effects in reducing
Document: Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, millions of people have been infected and died worldwide. However, no drug has been approved for the treatment of this disease and its complications, which urges the need for finding novel therapeutic agents to combat. Among the complications due to COVID-19, lung injury has attained special attention. Besides, phytochemicals have shown prominent anti-inflammatory effects and thus possess significant effects in reducing lung injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also, the prevailing evidence reveales the antiviral effects of those phytochemicals, including anti-SARS-CoV activity, which could pave the road in providing suitable lead compounds in the treatment of COVID-19. In the present study, candidate phytochemicals and related mechanisms of action have been shown in the treatment/protection of lung injuries induced by various methods. In terms of pharmacological mechanism, phytochemicals have shown potential inhibitory effects on inflammatory and oxidative pathways/mediators, involved in the pathogenesis of lung injury during COVID-19 infection. Also, a brief overview of phytochemicals with anti-SARS-CoV-2 compounds has been presented.
Search related documents:
Co phrase search for related documents- accessory protein and acute ards respiratory distress syndrome: 1
- acid derivative and acute ards respiratory distress syndrome: 1
- action main mechanism and acute ards respiratory distress syndrome: 1
- acute ards respiratory distress syndrome and administration dose: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute lung injury and administration dose: 1
- acute respiratory distress syndrome and administration dose: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- acute respiratory distress syndrome cause and administration dose: 1, 2, 3, 4
- acute respiratory syndrome coronavirus and administration dose: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34
- acute sars cov respiratory syndrome coronavirus and administration dose: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- additional study and administration dose: 1, 2
Co phrase search for related documents, hyperlinks ordered by date