Author: Joyner, M. J.; Klassen, S. A.; Senefeld, J.; Johnson, P. W.; Carter, R. E.; Wiggins, C. C.; Shoham, S.; Grossman, B. J.; Henderson, J. P.; Musser, J. M.; Salazar, E.; Hartman, W. R.; Bouvier, N. M.; Liu, S. T. H.; Pirofski, L.-a.; Baker, S. E.; Van Helmond, N.; Wright, R. S.; Fairweather, D.; Bruno, K. A.; Paneth, N. S.; Casadevall, A.
Title: Evidence favouring the efficacy of convalescent plasma for COVID-19 therapy Cord-id: 8zufbeuz Document date: 2020_7_30
ID: 8zufbeuz
Snippet: To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from randomized clinical trials, matched control, and case-series studies. Fixed-effects analyses demontrated that hospitalized COVID-19 patients transfused with convalescent plasma exhibited a a57% reduction in mortality rate (13%) compared to matched-patients receiving standard treatments (25%; OR: 0.43, P < 0.001). These data provide evidence favouring the efficacy of human convalescent pl
Document: To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from randomized clinical trials, matched control, and case-series studies. Fixed-effects analyses demontrated that hospitalized COVID-19 patients transfused with convalescent plasma exhibited a a57% reduction in mortality rate (13%) compared to matched-patients receiving standard treatments (25%; OR: 0.43, P < 0.001). These data provide evidence favouring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized COVID-19 patients.
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