Author: Jeffery-Smith, Anna; Iyanger, Nalini; Williams, Sarah V; Chow, J Yimmy; Aiano, Felicity; Hoschler, Katja; Lackenby, Angie; Ellis, Joanna; Platt, Steven; Miah, Shahjahan; Brown, Kevin; Amirthalingam, Gayatri; Patel, Monika; Ramsay, Mary E; Gopal, Robin; Charlett, Andre; Ladhani, Shamez N; Zambon, Maria
Title: Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020 Cord-id: 91xs4ova Document date: 2021_2_4
ID: 91xs4ova
Snippet: Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7–99.5%) using risk ratios from com
Document: Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7–99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8–99.3%) using a penalised logistic regression model.
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