Selected article for: "cell surface and SARS CoV host cell entry"
Author: Feria Hikmet; Loren Méar; Mathias Uhlén; Cecilia Lindskog
Title: The protein expression profile of ACE2 in human tissues
  • Document date: 2020_4_3
    • ID: 4fz6iqwy_2
    Snippet: When coronaviruses enter the target cell, a surface unit of the spike (S) glycoprotein binds to a cellular receptor. Upon entry, cellular proteases cleave the S protein which leads to fusion of the viral and cellular membranes. SARS-Cov has previously been shown to enter the cell via the ACE2 receptor, primed by the cellular serine protease TMPRSS2, and recent studies suggest that also SARS-CoV-2 employs ACE2 and TMPRSS2 for host cell entry 1 . T.....
    Document: When coronaviruses enter the target cell, a surface unit of the spike (S) glycoprotein binds to a cellular receptor. Upon entry, cellular proteases cleave the S protein which leads to fusion of the viral and cellular membranes. SARS-Cov has previously been shown to enter the cell via the ACE2 receptor, primed by the cellular serine protease TMPRSS2, and recent studies suggest that also SARS-CoV-2 employs ACE2 and TMPRSS2 for host cell entry 1 . The binding affinity of SARS-CoV-2 to ACE2 based on interaction between its S-protein and human ACE2 molecules using computational modelling seems to be weaker than that of SARS-CoV 2 , but the affinity is still considered to be high enough for human transmission.

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