Author: Feria Hikmet; Loren Méar; Mathias Uhlén; Cecilia Lindskog
Title: The protein expression profile of ACE2 in human tissues Document date: 2020_4_3
ID: 4fz6iqwy_2
Snippet: When coronaviruses enter the target cell, a surface unit of the spike (S) glycoprotein binds to a cellular receptor. Upon entry, cellular proteases cleave the S protein which leads to fusion of the viral and cellular membranes. SARS-Cov has previously been shown to enter the cell via the ACE2 receptor, primed by the cellular serine protease TMPRSS2, and recent studies suggest that also SARS-CoV-2 employs ACE2 and TMPRSS2 for host cell entry 1 . T.....
Document: When coronaviruses enter the target cell, a surface unit of the spike (S) glycoprotein binds to a cellular receptor. Upon entry, cellular proteases cleave the S protein which leads to fusion of the viral and cellular membranes. SARS-Cov has previously been shown to enter the cell via the ACE2 receptor, primed by the cellular serine protease TMPRSS2, and recent studies suggest that also SARS-CoV-2 employs ACE2 and TMPRSS2 for host cell entry 1 . The binding affinity of SARS-CoV-2 to ACE2 based on interaction between its S-protein and human ACE2 molecules using computational modelling seems to be weaker than that of SARS-CoV 2 , but the affinity is still considered to be high enough for human transmission.
Search related documents:
Co phrase search for related documents- cellular viral membrane fusion and host cell entry: 1, 2, 3, 4
- computational modelling and host cell: 1
- computational modelling and human transmission: 1
- host cell and human transmission: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43
- host cell and recent study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- host cell and SARS employ: 1, 2, 3
- host cell and spike surface unit: 1
- host cell and surface unit: 1, 2
- host cell and target cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- host cell entry and human transmission: 1, 2, 3, 4, 5, 6, 7, 8, 9
- host cell entry and recent study: 1, 2, 3
- host cell entry and SARS employ: 1, 2
- host cell entry and spike surface unit: 1
- host cell entry and surface unit: 1, 2
- host cell entry and target cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- human transmission and recent study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- human transmission and target cell: 1, 2
- recent study and target cell: 1, 2, 3
- spike surface unit and surface unit: 1
Co phrase search for related documents, hyperlinks ordered by date