Author: Kolberg, Espen Skarstein; Wickstrøm, Kristin; Tonby, Kristian; Dyrhol-Riise, Anne Ma; Holten, Aleksander Rygh; Amundsen, Erik Koldberg
Title: Serum ACE as a prognostic biomarker in COVID-19: A case series. Cord-id: 95vkzgdo Document date: 2020_12_23
ID: 95vkzgdo
Snippet: We have earlier proposed that serum ACE (s-ACE) could be used as a biomarker for severity in COVID-19 due to an assumed inverse relationship between ACE and ACE2. High s-ACE could indicate lower ACE2 activity and therefore more widespread and severe SARS-CoV2 infection, owing to virally mediated downregulation of ACE2 (1). Dysregulation of the Renin-Angiotensin-Aldosterone system (RAAS) are found in comorbidities known as risk factors for increased morbidity and mortality, such as hypertension a
Document: We have earlier proposed that serum ACE (s-ACE) could be used as a biomarker for severity in COVID-19 due to an assumed inverse relationship between ACE and ACE2. High s-ACE could indicate lower ACE2 activity and therefore more widespread and severe SARS-CoV2 infection, owing to virally mediated downregulation of ACE2 (1). Dysregulation of the Renin-Angiotensin-Aldosterone system (RAAS) are found in comorbidities known as risk factors for increased morbidity and mortality, such as hypertension and cardiovascular disease (2).
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