Author: Menéndez-Arias, Luis
Title: Decoding molnupiravir-induced mutagenesis in SARS-CoV-2 Cord-id: ilf9bkub Document date: 2021_6_9
ID: ilf9bkub
Snippet: Molnupiravir, a prodrug of the nucleoside derivative β-D-N(4)-hydroxycytidine (NHC), is currently in clinical trials for COVID-19 therapy. However, the biochemical mechanisms involved in molnupiravir-induced mutagenesis had not been explored. In a recent study, Gordon et al. demonstrated that NHC can be incorporated into viral RNA, and subsequently extended and used as template for RNA-dependent RNA synthesis, proposing a mutagenesis model consistent with available virological evidence. Their s
Document: Molnupiravir, a prodrug of the nucleoside derivative β-D-N(4)-hydroxycytidine (NHC), is currently in clinical trials for COVID-19 therapy. However, the biochemical mechanisms involved in molnupiravir-induced mutagenesis had not been explored. In a recent study, Gordon et al. demonstrated that NHC can be incorporated into viral RNA, and subsequently extended and used as template for RNA-dependent RNA synthesis, proposing a mutagenesis model consistent with available virological evidence. Their study uncovers molecular mechanisms by which molnupiravir drives SARS-CoV-2 into error catastrophe.
Search related documents:
Co phrase search for related documents- accurate determination and additional information: 1
- acute respiratory syndrome coronavirus and additional information: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome coronavirus and low mutational: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date