Author: Das, Subham; Anu, K.R.; Birangal, Sumit Raosaheb; Nikam, Ajinkya Nitin; Pandey, Abhijeet; Mutalik, Srinivas; Joseph, Alex
Title: Role of comorbidities like diabetes on severe acute respiratory syndrome coronavirus-2: A review Cord-id: deduos6e Document date: 2020_8_3
ID: deduos6e
Snippet: Pandemic coronavirus disease-2019, commonly known as COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious disease with a high mortality rate. Various comorbidities and their associated symptoms accompany SARS-CoV-2 infection. Among the various comorbidities like hypertension, cardiovascular disease and chronic obstructive pulmonary disease, diabetes considered as one of the critical comorbidity, which could affect the survival of infected patient
Document: Pandemic coronavirus disease-2019, commonly known as COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious disease with a high mortality rate. Various comorbidities and their associated symptoms accompany SARS-CoV-2 infection. Among the various comorbidities like hypertension, cardiovascular disease and chronic obstructive pulmonary disease, diabetes considered as one of the critical comorbidity, which could affect the survival of infected patients. The severity of COVID-19 disease intensifies in patients with elevated glucose level probably via amplified pro-inflammatory cytokine response, poor innate immunity and downregulated angiotensin-converting enzyme 2. Thus, the use of ACE inhibitors or angiotensin receptor blockers could worsen the glucose level in patients suffering from novel coronavirus infection. It also observed that the direct β-cell damage caused by virus, hypokalemia and cytokine and fetuin-A mediated increase in insulin resistance could also deteriorate the diabetic condition in COVID-19 patients. This review highlights the current scenario of coronavirus disease in pre-existing diabetic patients, epidemiology, molecular perception, investigations, treatment and management of COVID-19 disease in patients with pre-existing diabetes. Along with this, we have also discussed unexplored therapies and future perspectives for coronavirus infection.
Search related documents:
Co phrase search for related documents- abnormal glucose and ace receptor: 1
- ace inhibitor and acute ards respiratory distress syndrome: 1, 2, 3, 4
- ace inhibitor and acute cardiac injury: 1, 2
- ace inhibitor and acute phase: 1
- ace inhibitor and acute respiratory distress syndrome: 1, 2, 3, 4, 5
- ace receptor and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- ace receptor and acute cardiac injury: 1, 2, 3, 4, 5
- ace receptor and acute phase: 1, 2, 3
- ace receptor and acute respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- ace receptor and adaptive response: 1, 2, 3
- ace receptor bind and acute ards respiratory distress syndrome: 1
- ace receptor bind and acute respiratory distress syndrome: 1
- acquire infection and acute dialysis: 1
- acquire infection and acute phase: 1
- acquire infection and acute respiratory distress syndrome: 1
- active research and acute ards respiratory distress syndrome: 1, 2, 3
- active research and acute respiratory distress syndrome: 1, 2, 3, 4
- active research area and acute respiratory distress syndrome: 1
Co phrase search for related documents, hyperlinks ordered by date