Author: Niema Moshiri
Title: ViralMSA: Massively scalable reference-guided multiple sequence alignment of viral genomes Document date: 2020_4_21
ID: l9a7upui_11
Snippet: In order to test ViralMSA's accuracy, we obtained a curated HIV-1 full genome MSA from the Los Alamos National Laboratory (LANL) HIV Sequence Database, which we used as our ground truth. We then used both MAFFT and ViralMSA (using the HXB2 reference genome) to recompute MSAs. No other MSA tools were included in the comparison due to being orders of magnitude slower than MAFFT (which would render the full experiment infeasible)......
Document: In order to test ViralMSA's accuracy, we obtained a curated HIV-1 full genome MSA from the Los Alamos National Laboratory (LANL) HIV Sequence Database, which we used as our ground truth. We then used both MAFFT and ViralMSA (using the HXB2 reference genome) to recompute MSAs. No other MSA tools were included in the comparison due to being orders of magnitude slower than MAFFT (which would render the full experiment infeasible).
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