Author: K. Reddisiva Prasanth; Minato Hirano; W. Samuel Fagg; Eileen T. McAnarney; Chao Shan; Xuping Xie; Adam Hage; Colette A. Pietzsch; Alexander Bukreyev; Ricardo Rajsbaum; Pei-Yong Shi; Mark T. Bedford; Shelton S. Bradrick; Vineet Menachery; Mariano A. Garcia-Blanco
Title: Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses Document date: 2020_3_27
ID: a0xfb9l4_3
Snippet: A meta-analysis of RNAi-based loss-of-function screens for YFV and DENV-2 host factors revealed 274 common candidates 1 . TDRD3, a Tudor domain containing protein that interacts with methylated arginine motifs 5 , was identified as a candidate host factor required for both DENV2/YFV. In the two YFV screens TDRD3 ranked 66 th of over 21,500 gene products in terms of how well its knockdown decreased YFV (adjusted p value = 0.0006). CRISPR-Cas9 medi.....
Document: A meta-analysis of RNAi-based loss-of-function screens for YFV and DENV-2 host factors revealed 274 common candidates 1 . TDRD3, a Tudor domain containing protein that interacts with methylated arginine motifs 5 , was identified as a candidate host factor required for both DENV2/YFV. In the two YFV screens TDRD3 ranked 66 th of over 21,500 gene products in terms of how well its knockdown decreased YFV (adjusted p value = 0.0006). CRISPR-Cas9 mediated knockout of TDRD3 in HuH-7 cells confirmed that this protein was required for efficient DENV-2 replication (Fig 1A & B) .
Search related documents:
Co phrase search for related documents- arginine motif and protein contain: 1
- efficient replication and function loss: 1, 2
- efficient replication and gene product: 1, 2, 3
- efficient replication and host factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- function loss and gene product: 1, 2
- function loss and host factor: 1, 2, 3, 4
- function loss screen and host factor: 1
- gene product and host factor: 1
- gene product and protein contain: 1, 2
- host factor and protein contain: 1, 2
- host factor and YFV host factor: 1
Co phrase search for related documents, hyperlinks ordered by date