Author: A.J.W. Haasnoot; M.W. Schilham; S.S.M. Kamphuis; P.C.E. Hissink Muller; A. Heiligenhaus; D. Foell; R.A. Ophoff; T.R.D.J. Radstake; A.I. Den Hollander; T.H.C.M. Reinards; S. Hiddingh; N. Schalij-Delfos; E.P.A.H. Hoppenreijs; M.A.J. van Rossum; C. Wouters; R.K. Saurenmann; N. Wulffraat; R. ten Cate; J.H. de Boer; S.L. Pulit; J.J.W. Kuiper
Title: An amino acid motif in HLA-DRß1 distinguishes patients with uveitis in juvenile idiopathic arthritis Document date: 2017_5_22
ID: 4it5c9n2_9
Snippet: We performed separate GWAS in Phase 1 and Phase 2 and then combined the summarylevel results in an inverse variance-weighted fixed effects meta-analysis in METAL, 32 for a combined analysis of 330 non-uveitis JIA samples and 192 uveitis cases. Combining data, rather than performing a separate discovery and replication phase, improves power for discovery of novel association signals. 21 In the genome-wide scan, the single signal achieving genome-w.....
Document: We performed separate GWAS in Phase 1 and Phase 2 and then combined the summarylevel results in an inverse variance-weighted fixed effects meta-analysis in METAL, 32 for a combined analysis of 330 non-uveitis JIA samples and 192 uveitis cases. Combining data, rather than performing a separate discovery and replication phase, improves power for discovery of novel association signals. 21 In the genome-wide scan, the single signal achieving genome-wide significance (set at p < 2 x 10 -8 , after adjusting for three phenotype comparisons) resided in the MHC (Supplementary Figures 1 and 2) .
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