Author: Yasunori Watanabe; Zachary T. Berndsen; Jayna Raghwani; Gemma E. Seabright; Joel D. Allen; Jason S. McLellan; Ian A. Wilson; Thomas A. Bowden; Andrew B. Ward; Max Crispin
Title: Vulnerabilities in coronavirus glycan shields despite extensive glycosylation Document date: 2020_2_21
ID: bnnt05fn_28
Snippet: Although it is difficult to directly compare viruses in terms of immunogenic responses, on the one hand, SARS and MERS coronaviruses readily elicit neutralizing antibodies following infection or immunization [67] [68] [69] [70] . Indeed, many potential MERS CoV vaccine candidates are able to elicit high titres of serum IgG upon immunization but fail to produce sufficient mucosal immunity 70 . In contrast, the high mutation rate 71 and the evolvin.....
Document: Although it is difficult to directly compare viruses in terms of immunogenic responses, on the one hand, SARS and MERS coronaviruses readily elicit neutralizing antibodies following infection or immunization [67] [68] [69] [70] . Indeed, many potential MERS CoV vaccine candidates are able to elicit high titres of serum IgG upon immunization but fail to produce sufficient mucosal immunity 70 . In contrast, the high mutation rate 71 and the evolving glycan shield of HIV-1 24 , which firmly exemplifies it as "evasion strong" virus, hinders the development of broadly neutralizing antibodies 72 .Viruses classified as "evasion strong" 31, 59 may then differ due to varied efficacies of protein surface shielding by glycans.
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