Author: Hirooka, Yasuaki; Nozaki, Yuji
Title: Interleukin-18 in Inflammatory Kidney Disease Cord-id: 8a1xjl6b Document date: 2021_3_1
ID: 8a1xjl6b
Snippet: Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and strongly induces a Th1 response. IL-18 drives the same myeloid differentiation factor 88 (MyD88)/nuclear factor kappa B (NF-κB) signaling pathway as IL-1β. In physiological conditions, IL-18 is regulated by the endogenous inhibitor IL-18 binding protein (IL-18BP), and the activity of IL-18 is balanced. It is
Document: Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and strongly induces a Th1 response. IL-18 drives the same myeloid differentiation factor 88 (MyD88)/nuclear factor kappa B (NF-κB) signaling pathway as IL-1β. In physiological conditions, IL-18 is regulated by the endogenous inhibitor IL-18 binding protein (IL-18BP), and the activity of IL-18 is balanced. It is reported that in several inflammatory diseases, the IL-18 activity is unbalanced, and IL-18 neutralization by IL-18BP is insufficient. IL-18 acts synergistically with IL-12 to induce the production of IFN-γ as a Th1 cytokine, and IL-18 acts alone to induce the production of Th2 cytokines such as IL-4 and IL-13. In addition, IL-18 alone enhances natural killer (NK) cell activity and FAS ligand expression. The biological and pathological roles of IL-18 have been studied in many diseases. Here we review the knowledge regarding IL-18 signaling and the role of IL-18 in inflammatory kidney diseases. Findings on renal injury in coronavirus disease 2019 (COVID-19) and its association with IL-18 will also be presented.
Search related documents:
Co phrase search for related documents- acute ards respiratory distress syndrome and adhesion molecule expression: 1, 2
- acute ards respiratory distress syndrome and liver enzyme: 1, 2, 3, 4
- acute ards respiratory distress syndrome and low affinity: 1
- acute ards respiratory distress syndrome and lps induce: 1, 2, 3, 4, 5, 6
- acute ards respiratory distress syndrome and lps injection: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and lupus erythematosus: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and lupus nephritis: 1
- acute ards respiratory distress syndrome and macrophage neutrophil: 1, 2, 3, 4, 5, 6
- acute ards respiratory distress syndrome and macrophage neutrophil infiltration: 1, 2
- adhesion molecule and liver enzyme: 1
- adhesion molecule and lps induce: 1
- adhesion molecule and lps injection: 1, 2
- adhesion molecule and lymphocyte specific: 1
- adhesion molecule expression and lps injection: 1
- liver enzyme and lps induce: 1
- lps injection and macrophage neutrophil: 1
Co phrase search for related documents, hyperlinks ordered by date