Author: Danielle E Anderson; Jin Cui; Qian Ye; Baoying Huang; Wenhong Zu; Jing Gong; Weiqiang Liu; So Young Kim; Biao Guo Yan; Kristmundur Sigmundsson; Xiao Fang Lim; Fei Ye; Peihua Niu; Xuming Zhou; Wenjie Tan; Lin-Fa Wang; Xu Tan
Title: Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy Document date: 2020_3_30
ID: 0l33i6s4_16
Snippet: significantly reduced viral infection and 45 host restriction factors whose knockdown promoted 10 viral infection based on the Z score of infection rate (Fig. 1d) . We selected a number of genes for 11 individual validation with more replicates and obtained a high validation rate (11/12 of host 12 dependency factors and 7/12 of the host restriction factors validated with at least one siRNA) 13 ( Supplementary Fig. 3) , supporting the reproducibil.....
Document: significantly reduced viral infection and 45 host restriction factors whose knockdown promoted 10 viral infection based on the Z score of infection rate (Fig. 1d) . We selected a number of genes for 11 individual validation with more replicates and obtained a high validation rate (11/12 of host 12 dependency factors and 7/12 of the host restriction factors validated with at least one siRNA) 13 ( Supplementary Fig. 3) , supporting the reproducibility of our screening methodology. 14 15
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