Author: Xavier Hernandez-Alias; Martin Schaefer; Luis Serrano
Title: Translational adaptation of human viruses to the tissues they infect Document date: 2020_4_7
ID: 0rk2dw4e_33
Snippet: On the other hand, it is known that host tRNA pools undergo reprogramming upon viral infection of HIV-1, vaccinia virus, and influenza A virus 17, 52 . In this context, differences in codon usage between early and late viral genes have been previously reported, but the directionality of such changes remained unclear 10, 53 . Based on our concept of tissue-specific adaptation, we therefore validate that early replication-related proteins are bette.....
Document: On the other hand, it is known that host tRNA pools undergo reprogramming upon viral infection of HIV-1, vaccinia virus, and influenza A virus 17, 52 . In this context, differences in codon usage between early and late viral genes have been previously reported, but the directionality of such changes remained unclear 10, 53 . Based on our concept of tissue-specific adaptation, we therefore validate that early replication-related proteins are better adapted to the tissue of infection. Upon infection, we then unveil that changes in tRNA abundance switch the adaptation towards the expression of late structural proteins, confirming a general trend that had previously only been observed in HIV-1 17 .
Search related documents:
Co phrase search for related documents- late early viral gene and vaccinia virus: 1
- late early viral gene and viral gene: 1, 2, 3, 4, 5
- late structural protein and structural protein: 1
- late structural protein and vaccinia virus: 1
- previously report and structural protein: 1
- previously report and viral gene: 1, 2, 3
- previously report and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- replication relate and vaccinia virus: 1
- replication relate and viral infection: 1
- structural protein and vaccinia virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- structural protein and viral gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31
- structural protein and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- trna pool and viral gene: 1
- trna pool and viral infection: 1, 2, 3
- vaccinia virus and viral gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- vaccinia virus and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36
- vaccinia virus viral infection and viral infection: 1
Co phrase search for related documents, hyperlinks ordered by date