Author: Xavier Hernandez-Alias; Martin Schaefer; Luis Serrano
Title: Translational adaptation of human viruses to the tissues they infect Document date: 2020_4_7
ID: 0rk2dw4e_33
Snippet: On the other hand, it is known that host tRNA pools undergo reprogramming upon viral infection of HIV-1, vaccinia virus, and influenza A virus 17, 52 . In this context, differences in codon usage between early and late viral genes have been previously reported, but the directionality of such changes remained unclear 10, 53 . Based on our concept of tissue-specific adaptation, we therefore validate that early replication-related proteins are bette.....
Document: On the other hand, it is known that host tRNA pools undergo reprogramming upon viral infection of HIV-1, vaccinia virus, and influenza A virus 17, 52 . In this context, differences in codon usage between early and late viral genes have been previously reported, but the directionality of such changes remained unclear 10, 53 . Based on our concept of tissue-specific adaptation, we therefore validate that early replication-related proteins are better adapted to the tissue of infection. Upon infection, we then unveil that changes in tRNA abundance switch the adaptation towards the expression of late structural proteins, confirming a general trend that had previously only been observed in HIV-1 17 .
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