Author: Jing Qi; Yang Zhou; Jiao Hua; Liying Zhang; Jialin Bian; Beibei Liu; Zicen Zhao; Shuilin Jin
Title: The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection Document date: 2020_4_18
ID: grvc7pnt_12
Snippet: The expression level of ACE2 in AT2 cells is the primary reference to infer the susceptibility of other organs and tissues. The ratio of ACE2-expressed cells over total AT2 cells is 0· 79% which is the mean of 8 samples. To determine the susceptibility of the organs, the expression level of TMPRSS2 is another reference. The cell cluster, in which TMPRSS2 is expressed and ACE2-expressed cell ratio is equal to or greater than AT2 cells at the same.....
Document: The expression level of ACE2 in AT2 cells is the primary reference to infer the susceptibility of other organs and tissues. The ratio of ACE2-expressed cells over total AT2 cells is 0· 79% which is the mean of 8 samples. To determine the susceptibility of the organs, the expression level of TMPRSS2 is another reference. The cell cluster, in which TMPRSS2 is expressed and ACE2-expressed cell ratio is equal to or greater than AT2 cells at the same time, is identified as highly susceptible cells, and the corresponding organs are vulnerable to COVID-19.
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