Author: Jing Qi; Yang Zhou; Jiao Hua; Liying Zhang; Jialin Bian; Beibei Liu; Zicen Zhao; Shuilin Jin
Title: The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection Document date: 2020_4_18
ID: grvc7pnt_41
Snippet: The clinical symptoms of patients infected by COVID are mainly manifested in the respiratory system and digestive system, including cough, shortness of breath, dyspnea, and diarrhea. However, some patients also developed symptoms such as heart damage and kidney failure, indicating that the virus affected the normal function of the circulatory and urinary systems. We investigated the susceptibility of the organs and tissues in various human system.....
Document: The clinical symptoms of patients infected by COVID are mainly manifested in the respiratory system and digestive system, including cough, shortness of breath, dyspnea, and diarrhea. However, some patients also developed symptoms such as heart damage and kidney failure, indicating that the virus affected the normal function of the circulatory and urinary systems. We investigated the susceptibility of the organs and tissues in various human systems based on the scRNA-seq data analysis. In details, 31 organs from nine major human systems were considered, in which 11 organs are identified to be susceptible to the virus. Moreover, we classified these susceptible organs into three levels in terms of their risk, which provide novel ideas for the follow-up detection of virus, treatment, and the monitoring of recrudescence.
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