Author: Paul A. Rowley; Brandon Ho; Sarah Bushong; Arlen Johnson; Sara L. Sawyer
Title: XRN1 is a Species-Specific Virus Restriction Factor in Yeasts Document date: 2016_8_16
ID: 1znuxoj5_3
Snippet: We next used a functional and quantitative assay to confirm the species-specific 229 effects of XRN1 on virus replication. This assay exploits the dsRNA "killer virus" (also 230 known as M virus). The killer virus is a satellite RNA of L-A and is totally dependent on 231 L-A proteins for replication. It uses L-A-encoded proteins to encapsidate and replicate 232 its genome, and to synthesize and cap its RNA transcripts [12] . The killer virus enco.....
Document: We next used a functional and quantitative assay to confirm the species-specific 229 effects of XRN1 on virus replication. This assay exploits the dsRNA "killer virus" (also 230 known as M virus). The killer virus is a satellite RNA of L-A and is totally dependent on 231 L-A proteins for replication. It uses L-A-encoded proteins to encapsidate and replicate 232 its genome, and to synthesize and cap its RNA transcripts [12] . The killer virus encodes 233 only a single protein, a secreted toxin referred to as the killer toxin [19, 55, 56] . The result 234 is that "killer yeast" colonies, i.e. those infected with both L-A and the killer virus, kill 235 neighboring cells via the diffusion of toxin into the surrounding medium ( Fig 2C) .
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